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Adv Drug Deliv Rev. 2013 Nov;65(13-14):1699-715. doi: 10.1016/j.addr.2013.04.011. Epub 2013 Apr 20. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor.

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Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specifi … Pris: 1619 kr. Inbunden, 2018. Skickas inom 5-8 vardagar. Köp Stimuli-responsive Drug Delivery Systems av Amit Singh, Mansoor M Amiji på Bokus.com. pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1).

Drugs in Horses: Pharmacokinetics and Pharmacodynamics

Stimuli-responsive particles could find use in numerous applications in the chemical, coatings, cosmetic, detergent and food industries, as well as drug delivery and diagnostics where the stimuli Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation. Polyethylene oxide/polypropylene oxide co-block or triblock polymers and polymethacrylates are thermal- and pH-responsive polymer groups, resp. but both have proven to have successful activity and contribution in The main feature of a stimuli-responsive nanocarrier is the ability to undergo specific structural modifications in response to internal or external stimuli in order to enhance cellular internalization and drug release in the diseased site, while remaining stable in the systemic circulation [39,40].

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery

2021-03-16 · Covalent organic frameworks (COFs) have received much attention in the biomedical area. However, little has been reported about stimuli-responsive COF for drug delivery. Herein, we synthesized a hypoxia-responsive azo bond-containing COF with nanoscale size and immobilized both photosensitizers chlorin e6 (Ce6) and hypoxia-activated drug tirapazamine (TPZ) into the COFs. When such a COF In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target. A greater amount of MRSA in the system will lead to more release of drug and vice versa.

Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. These materials are responsive to a variety of triggers such as pH, reducing conditions, temperature, glucose, and enzymes that can be tuned based on their chemistry for various The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting. Stimuli-responsive particles could find use in numerous applications in the chemical, coatings, cosmetic, detergent and food industries, as well as drug delivery and diagnostics where the stimuli Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation. Polyethylene oxide/polypropylene oxide co-block or triblock polymers and polymethacrylates are thermal- and pH-responsive polymer groups, resp. but both have proven to have successful activity and contribution in The main feature of a stimuli-responsive nanocarrier is the ability to undergo specific structural modifications in response to internal or external stimuli in order to enhance cellular internalization and drug release in the diseased site, while remaining stable in the systemic circulation [39,40]. Due to the presence of pH and redox Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives ACS Nano , 12 ( 2018 ) , pp. 10636 - 10664 Google Scholar
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ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the drug. Hydrogels are the upcoming class of biomaterials, which act as excellent drug delivery systems. These materials have important characteristic feature that they respond to various external stimuli like pH, light, temperature, magnetic field, electric field and pressure.

The traditional design of stimuli-responsive NMs is based on the incorporation of drug molecules into the nanocarrier, which is prepared from pH-sensitive building blocks. However, under acidic conditions, drug delivery systems tend to demonstrate burst drug release instead of extended-release.
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Enzyme-responsive nanoparticles for drug release and - DiVA

However, the precise control of payload release from a dendrimer matrix still presents a great challenge. Stimuli-responsive dendrimers that release payloads in response … Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems Xing Qin Laboratory of Low-Dimensional Materials Chemistry, Key … Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics Peng Mi Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 South Renmin Road, Chengdu, 610041, China Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. polymers Review Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis Sabya Sachi Das 1, Priyanshu Bharadwaj 2, Muhammad Bilal 3, Mahmood Barani 4, Abbas Rahdar 5,* , Pablo Taboada 6,7, Simona Bungau 8 and George Z. Kyzas 9,* 1 Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Stimuli-responsive drug-delivery systems have emerged as potential tools for advanced treatment of cancers. Versatile nano-carriers co-triggered by multiple stimuli in different levels of organisms (eg, extracorporeal, tumor tissue, cell, subcellular organelles) In this work, we report a smart stimuli-responsive drug delivery system (DDS) that can release drug depending upon the amount of pathogen (MRSA) present in the target. A greater amount of MRSA in the system will lead to more release of drug and vice versa. Carbon-dot-coated novel alginate beads (CA-CD) exhibiting superior stability was successfully used as smart drug delivery vehicle. Garlic Title: Stimuli-Responsive Molecularly Imprinted Polymers for Drug Delivery: A Review VOLUME: 5 ISSUE: 2 Author(s):Francesco Puoci, Francesca Iemma and Nevio Picci Affiliation:Dipartimento di Scienze Farmaceutiche, Universita della Calabria - Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy.